Leqvio is promoted as a stand-alone cholesterol-lowering treatment in patients at risk of cardiovascular disease.
Swiss pharmaceutical company Novartis has announced positive results for Leqvio, a cholesterol-lowering drug currently in Phase 3 clinical trials. According to the company’s statement, the drug met its primary endpoints in the trial. “Leqvio monotherapy achieved a clinically meaningful and statistically significant reduction in low-density lipoprotein cholesterol (LDL-C) compared to placebo and ezetimibe in patients at low or moderate risk of developing atherosclerotic cardiovascular disease (ASCVD) and not receiving lipid-lowering therapy,” the company said in a statement.
According to Novartis, Leqvio is promoted as a stand-alone treatment to lower cholesterol in patients at risk of ASCVD, a common condition that leads to cardiovascular diseases such as coronary heart disease and peripheral artery disease, when plaque builds up in the arteries, narrowing them and reducing blood flow to organs.
V-MONO is the first trial evaluating a small interfering RNA (siRNA) therapy taken as a monotherapy to reduce low-density lipoprotein. The company says it plans to present the results of this trial at an upcoming medical meeting and share them with regulatory agencies, including the U.S. Food and Drug Administration.
In addition, Novartis is also conducting other studies exploring the use of Leqvio in the primary and secondary prevention of ASCVD. These studies aim to further consolidate the role of Leqvio in cholesterol control, with key results expected to be available between 2024 and 2027.
According to press reports, VICTORION-1-PREVENT or V1P is the only study dedicated to a non-statin lipid-lowering therapy in a high-risk primary prevention population as defined by the American College of Cardiology and American Heart Association guidelines; this outcome study is expected to complete enrollment later this year.
Ways to keep cholesterol levels under control
According to experts, some natural strategies to keep cholesterol levels under control include:
Eat healthy
Doctors recommend choosing foods low in saturated and trans fats, sodium and added sugars. Incorporate more fruits, vegetables and whole grains, and smaller amounts of eggs and lean poultry.
Exercise
According to the Department of Health and Human Services, adults should get at least 150 to 300 minutes of moderate-intensity aerobic exercise or 75 to 150 minutes of vigorous-intensity aerobic exercise each week. You can spread this activity out throughout the week and can start with lower-intensity activities and work your way up to higher-intensity activities.
Quit smoking and drinking alcohol
Both smoking and drinking alcohol can be disastrous not only for your heart but also for your overall health.
Managing stress
Several studies have said that stress can cause high cholesterol levels, which if left unchecked can be detrimental to heart health and lead to life-threatening diseases like heart attacks and strokes.
Disclaimer
The information contained in this post is for general information purposes only. We make no representations or warranties of any kind, express or implied, about the completeness, accuracy, reliability, suitability or availability with respect to the website or the information, products, services, or related graphics contained on the post for any purpose.
We respect the intellectual property rights of content creators. If you are the owner of any material featured on our website and have concerns about its use, please contact us. We are committed to addressing any copyright issues promptly and will remove any material within 2 days of receiving a request from the rightful owner.